The Secretariat of the United Human is responsible for handling the daily work entrusted by the Assembly and other main bodies. The Secretariat is composed of thousands of United Human staff from all over the world, representing various corners and communities globally, and includes hundreds of thousands of volunteers. They all work towards achieving the mission and goals of the United Human.

The Secretariat is headed by one Secretary-General and several Deputy Secretary-Generals. It is divided into multiple departments, each coordinating with one another to ensure unified implementation of the United Human’ work plans and related affairs.